Association of COL1A1 Sp1-binding site polymorphism with susceptibility to pelvic organ prolapse: a meta-analysis

Introduction: Growing studies explored the association of polymorphism in C0L1A1 Sp1-binding site with susceptibility to pelvic organ prolapse (POP), but the results have remained controversial and conflicting. To investigate the effect of COL1A1 Sp1-binding site polymorphism on POP, we performed a meta-analysis. Methods: We searched PubMed and HuGE for case-control studies concerning the association between COL1A1 Sp1-binding site polymorphism and POP from 1980 to July 1, 2015. Pooled analysis of the data in qualified reports has been performed by Stata 12.0. Result: In all, four published case-control studies including 698 participants were contained in quantitative syntheses. In the overall meta-analysis, an increased POP risk was detected in the heterozygous model of COL1A1 Sp1-binding site polymorphisms (GT vs. GG: OR=1.43, 95% CI, 1.02-2.00, P=0.040). Conclusion: The overall results suggest that COL1A1 Sp1-binding site polymorphisms may be associated with an increased POP risk.